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Negative results/Null result
Null resultRecorded 12 Sep 2026 · checked by Dr. R. Moreau · pre-registered · Illustrative

Null results

Null results are recorded as findings in their own right, with the same proof as any other contribution. The record below is an illustrative example of one.

Probiotic dosing did not reduce thermal stress in Pocillopora under +2°C

A pre-registered tank experiment found no difference in thermal stress between colonies given a probiotic mix and controls. It tested a 2024 claim of a 30% reduction.

The claim tested
A three-strain probiotic reduced thermal stress in Pocillopora by 30% under +2°C heat stress.
Santos et al. (2024), Frontiers in Marine Science
Design
Colonies96 (48 per group)
Heat stress+2°C for 21 days
OutcomeThermal stress score, blinded
Pre-registeredOSF · 3 Feb 2026
ResultEffect on thermal stress, this study vs the original
Difference of 2 percentage points (95% CI −6 to 10). Not distinguishable from zero.
Original claim −30%0+30%
Expert check
Design and analysis sound“Adequately powered to detect a 15-point effect. Dosing matched the original protocol.”, Dr. R. Moreau
Lab
UHA second independent lab3 members credited
Linked to
Living review LR-0142Included
Replication call · probioticsResult recorded
Data · 96-colony scoresOn the record